This contrasts with the highly lipid-soluble diazepam, which, although rapidly absorbed orally or rectally, soon redistributes from the serum to other parts of the body, in particular body fat.

4%). Withdrawal symptoms can range from anxiety and insomnia to seizures and psychosis. Lorazepam's effects are dose-dependent, meaning the higher the dose, the stronger the effects (and side effects) will be. Toxicity from propylene glycol has been reported in the case of a patient receiving a continuous lorazepam infusion. As lorazepam can have paradoxical effects, haloperidol is sometimes given concomitantly. Clinical example: Diazepam has long been a drug of choice for status epilepticus: Its high lipid solubility means it gets absorbed with equal speed whether given intravenously, orally, or rectally (non-intravenous routes are convenient in non-hospital settings). See also: Ativan pregnancy and breastfeeding warnings (in more detail)The sedative effects of this medication may last longer in older adults. What happens if I miss a dose?Take the missed dose as soon as you remember. Withdrawal symptoms can range from anxiety and insomnia to seizures and psychosis. The anxiolytic effects may also be detrimental to a patient's willingness and ability to fight for breath.