High dose or prolonged parentally administered lorazepam is sometimes associated with propylene glycol intoxication.

It takes approximately 18–36 hours for the benzodiazepine to remove itself from the body. Increasing the dose may overcome tolerance, but tolerance may then develop to the higher dose and adverse effects may persist and worsen. As a result dosage recommendations for the elderly are about half of those used in younger individuals and used for no longer than two weeks. * Myasthenia gravis – This condition is characterised by muscle weakness and a muscle relaxant such as lorazepam may exacerbate symptoms. Ativan should never be shared with another person, especially someone who has a history of drug abuse or addiction. The drug was developed by President of Research, D. Do not give this medication to a child younger than 12 years old. S. edit ChemistryLorazepam is synthesized according to a scheme containing some of the same elements for the synthesis of chlordiazepoxide and oxazepam. They can add to sleepiness caused by this medication.