Food and Drug Administration (FDA) or visit www.

If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Synergistic adverse effects may also occur when lorazepam is administered with other drugs such as opioids or other hypnotics. Lorazepam is metabolised in the liver by conjugation into inactive lorazepam-glucuronide. Lorazepam (initially marketed under the brand names Ativan and Temesta) is a high-potency short-to-intermediate-acting 3-hydroxy benzodiazepine drug that has all five intrinsic benzodiazepine effects: anxiolytic, amnesic, sedative/hypnotic, anticonvulsant and muscle relaxant. The solvents used are polyethylene glycol 400 and propylene glycol. The marked anticonvulsant properties of lorazepam, and its pharmacokinetic profile, make intravenous lorazepam a reliable agent for terminating acute seizures, but it has relatively prolonged sedation after-effects. On regular administration, maximum lorazepam serum levels are attained after three days. Lorazepam is used for the short-term treatment of anxiety, insomnia, acute seizures including status epilepticus and sedation of hospitalised patients, as well as sedation of aggressive patients. Tell your doctor about all the prescription and over-the-counter medications you use. Peak effects roughly coincide with peak serum levels, which occur 10 minutes after intravenous injection, up to 60 minutes after intramuscular injection, and 90 to 120 minutes after oral administration, but initial effects will be noted before this.